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Faraway teQTL “hotspots” are learn bodies away from cardiac interpretation Upstream ORFs (uORFs) are major cis regulatory elements of translation located in 5? leader sequences of protein-coding mRNAs , and genetic variants interfering with these elements can affect the efficiency of mRNA translation . Out of over a thousand newly detected uORFs per tissue (Additional file 1: Figure S1H and Additional file 4: Table S3), we detected 27 (center) and 13 (the liver) uORFs whose translation rates associated with genetic...

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